Sources
Sixteen, and the rule that governs this list: nothing is cited on this site that was not opened and read. No study is referenced that does not appear here.
- Chromium — Fact Sheet for Health ProfessionalsNIH Office of Dietary SupplementsDaily Value 35 mcg; Adequate Intake 35 mcg for men and 25 mcg for women aged 19–50; chromium-only supplements typically provide 200–500 mcg; diabetes trials used 1.28 to 1,000 mcg daily, most often as picolinate; about 1.2% of chromium is absorbed from chromium picolinate; no Tolerable Upper Intake Level was established; there is “insufficient rationale to recommend chromium supplements for people with type 2 diabetes.”
- Dietary Supplements for Exercise and Athletic PerformanceNIH Office of Dietary SupplementsBeta-alanine 1.6–6.4 g a day; arginine 2–20 g a day, which “provided little or no enhancement of athletic performance”; glutamine at 0.3 g per kg of body weight and up to almost 45 g a day; little support for ginseng in athletic performance.
- Carnitine — Fact Sheet for Health ProfessionalsNIH Office of Dietary Supplements1 to 4 g a day in athletic-performance studies; supplemental L-carnitine bioavailability about 14% to 18% against 63% to 75% for dietary carnitine.
- Dietary Supplement Labeling Guide, Chapter IV: Nutrition LabelingU.S. Food and Drug AdministrationBlend ingredients must be listed “in descending order of predominance by weight” with the blend's total weight on the same line; ingredients with an RDI or DRV must be listed separately with their individual weights declared. 21 CFR 101.36(b)(2) and (c).
- FDA 101: Dietary SupplementsU.S. Food and Drug Administration“The FDA does NOT have the authority to approve dietary supplements for safety and effectiveness, or to approve their labeling, before the supplements are sold to the public”; a product intended to treat, prevent or cure a disease is a drug, whatever it is labelled.
- Paws Off Xylitol; It's Dangerous for DogsU.S. Food and Drug AdministrationXylitol appears in many products including dietary supplements; in dogs it “may result in a potent release of insulin” and “a rapid and profound decrease in the level of blood sugar” within 10 to 60 minutes. FDA advises checking labels and keeping such products out of reach.
- Gymnema — clinical monographDrugs.com natural products database“Clinical studies investigating antidiabetic effects have typically used 200 or 400 mg extract daily standardized to contain 25% gymnemic acids”; 500 to 1,000 mg a day of leaf extract in diabetes trials; “Few methodologically sound clinical studies exist.”
- Green Tea — clinical monographDrugs.com natural products databaseCatechins or extract at 160 to 2,488 mg a day; an EGCG range of 84 to 386 mg a day for diabetes support; green tea extract should not be taken on an empty stomach because plasma EGCG rises fivefold in the fasted state.
- Guarana — clinical monographDrugs.com natural products database“Doses ranging from 75 mg to 1,000 mg daily have been used in limited clinical trials”; guarana seed is 3% to greater than 5% caffeine by dry weight against approximately 1% to 2% for coffee beans.
- Ginseng — clinical monographDrugs.com natural products databaseCrude root 0.5 to 3 g a day; “the dose of extracts has generally ranged from 100 to 400 mg”; glucose improvements reported in some studies but not others.
- Forskolin — clinical monographDrugs.com natural products database“Oral forskolin has been studied using 10 mg daily over 2 to 6 months”; 250 mg of a 10% forskolin extract twice daily for 12 weeks in obesity work.
- Maca — clinical monographDrugs.com natural products database1.5 to 3 g a day of gelatinised maca root over 12 weeks; 1,500 mg reported not effective and 3,000 mg effective in one SSRI-related trial.
- Grape Seed — clinical monographDrugs.com natural products databaseOral doses of 150 to 2,000 mg a day over 2 to 24 weeks.
- Astragalus — clinical monographDrugs.com natural products database“Clinical trial data are lacking to guide dosing recommendations for A. membranaceus products.”
- Licorice — clinical monographDrugs.com natural products database“The acceptable daily intake (ADI) for glycyrrhizin is suggested to be 0.2 mg/kg/day”, with a proposed no-observed-effects level of 2 mg/kg/day; mineralocorticoid hypertension has been produced by as little as 50 g a day of licorice.
- Health Products Compliance GuidanceU.S. Federal Trade Commission“Testimonials that report results more dramatic than users can generally expect are likely to be deceptive”; randomised controlled human trials are “the most reliable form of evidence” for health-benefit claims.
How this site uses them
- Every milligram figure on this site is either printed on the label artwork or divided out from one that is.
- Every Daily Value, Adequate Intake and absorption figure comes from the NIH Office of Dietary Supplements fact sheet for that nutrient.
- Every statement about what a proprietary blend must declare comes from FDA's own labeling guide, with the CFR citation.
- Every published dose used for comparison is the smallest the cited source reports, which is the reading most generous to the label.
- For ten of the twenty-one blend ingredients no daily amount was found in a source this site could open. That is written down rather than filled in, and one of the ten — astragalus — has a monograph that says so itself.